1. Improving expression lines - a well-known effect of snake venom peptide.
SYN-AKE (also known as snake venom peptide) is a synthetic tripeptide named for its mechanism of action, which mimics that of the snake venom Waglerin-1. It was successfully synthesized by Royal DSM in the Netherlands in 2007 and applied to skincare products. It also won the BSB European Innovation Award for Active Ingredients in the Swiss Technology Awards. Waglerin-1 is a component of the venom of the Temple Viper snake. SYN-AKE is a tripeptide obtained by mimicking the key amino acid sequence of Waglerin-1. It has been proven to antagonistically bind to the acetylcholine receptor ε-subunit (located at the neuromuscular junction), blocking the transmission of sodium ion signals, thereby inhibiting muscle movement and smoothing/reducing skin wrinkles.
In one experiment, 100 mothers (50-65 years old) and their daughters (21-35 years old) were selected as subjects and divided into four groups. Primoslite (a 3D measurement system) was used to record the facial expressions of both mothers and daughters in relaxed and tense states. The results showed that daughters with tense facial expressions had similar wrinkle patterns to their mothers with relaxed facial expressions, suggesting that the daughters' wrinkle patterns in later life are highly likely to be the same as their mothers'.
In subsequent tests, both the mother and daughter used a cream containing 4% SYN-AKE and a placebo for comparison, twice daily for four weeks. Scientists again measured similar wrinkles on the mother and daughter using Primoslite. The results showed a reduction in both the mother's wrinkles and the daughter's fine lines, demonstrating that SYN-AKE can reduce the appearance of deep wrinkles and, if used early, can delay the formation of expression lines and slow down the aging process.
2. Improve deep wrinkles
Over time, intrinsic and extrinsic aging processes cause significant changes in the structure of the dermis and epidermis: the collagen density in the dermis decreases, and the collagen network becomes fragmented, exhibiting shorter, more disorganized fibers. Simultaneously, increased expression of matrix metalloproteinases (MMPs) accelerates collagen degradation, while the rate at which dermal fibroblasts synthesize new extracellular matrix components slows down, failing to adequately replace the degraded matrix. This series of changes leads to the appearance of deep wrinkles and dry skin.
New research data suggests that SYN-AKE can improve established wrinkles through mechanisms that improve various dermal structures.
① Increase the expression level of the PLOD3 gene.
PLOD3 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3) is an important enzyme that plays a crucial role in regulating collagen IV synthesis and maintaining basement membrane homeostasis. It helps improve the quality of collagen fibers in the dermis and dermal-epidermal junction, thus aiding in skin self-repair. In vitro experiments have shown that SYN-AKE can increase PLOD3 gene expression in fibroblasts from both young and elderly individuals, thereby improving collagen fiber quality.
② Promotes the synthesis of type III collagen and hyaluronic acid.
Healthy fibroblasts produce collagen, elastin, and various extracellular matrix components such as hyaluronic acid and fibers, providing the skin with elasticity, vitality, and a youthful appearance. As we age, when the rate at which dermal fibroblasts synthesize new extracellular matrix components falls below the rate of degradation, the levels of type III collagen and hyaluronic acid in the skin gradually decrease. According to in vitro experiments, SYN-AKE can promote the synthesis of type III collagen and hyaluronic acid, plumping the skin from within.
1. Reduces oiliness, resulting in flawless skin.
DPP4 (dipeptidyl peptidase) is a key enzyme in various skin-based biological processes. Its overactivity can lead to excessive sebum production, inflammation, and keratinocyte overproliferation, resulting in problems such as oily skin, irritation, redness, and acne.
In vitro and in vivo experiments have demonstrated that SYN-AKE has a dose-dependent inhibitory effect on DPP4. By inhibiting DPP4 activity, SYN-AKE can regulate sebum secretion and improve oily skin.
Xi'an Jenifer Technology Co., Ltd.'s SYN-AKE peptide boasts high purity (≥98%) and exceptional stability, with rigorous quality control applied from raw materials to finished products. Manufactured in a GMP-compliant facility, the product meets international standards and is tested by independent third-party organizations, ensuring consistent and reliable quality.
With its powerful skin penetration and targeted anti-wrinkle activity, our SYN-AKE effectively relaxes facial muscle contractions, reduces fine lines and wrinkles, and improves skin smoothness and elasticity. It is widely used in high-end anti-aging, firming, and repairing skincare formulations, providing stable and long-lasting efficacy for your final products.